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active human hpse  (Bio-Techne corporation)


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    Bio-Techne corporation active human hpse
    <t>HPSE</t> activity is dose-dependently inhibited by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide. Dose response inhibition <t>of</t> <t>recombinant</t> human HPSE with (A) unstimulated HS glx (B) . LPS HS glx , (C) . fucoidan and (D) . sulodexide. Data are expressed as mean ± SEM. Unstimulated HS glx , HS extracted from unstimulated endothelial glycocalyx; LPS HS glx , HS extracted from LPS stimulated endothelial glycocalyx; HPSE, heparanase-1.
    Active Human Hpse, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 94/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/active human hpse/product/Bio-Techne corporation
    Average 94 stars, based on 27 article reviews
    active human hpse - by Bioz Stars, 2026-04
    94/100 stars

    Images

    1) Product Images from "Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis"

    Article Title: Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis

    Journal: Frontiers in Molecular Biosciences

    doi: 10.3389/fmolb.2023.1223972

    HPSE activity is dose-dependently inhibited by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide. Dose response inhibition of recombinant human HPSE with (A) unstimulated HS glx (B) . LPS HS glx , (C) . fucoidan and (D) . sulodexide. Data are expressed as mean ± SEM. Unstimulated HS glx , HS extracted from unstimulated endothelial glycocalyx; LPS HS glx , HS extracted from LPS stimulated endothelial glycocalyx; HPSE, heparanase-1.
    Figure Legend Snippet: HPSE activity is dose-dependently inhibited by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide. Dose response inhibition of recombinant human HPSE with (A) unstimulated HS glx (B) . LPS HS glx , (C) . fucoidan and (D) . sulodexide. Data are expressed as mean ± SEM. Unstimulated HS glx , HS extracted from unstimulated endothelial glycocalyx; LPS HS glx , HS extracted from LPS stimulated endothelial glycocalyx; HPSE, heparanase-1.

    Techniques Used: Activity Assay, Inhibition, Recombinant



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    Relation between <t>HPSE1</t> and HPSE2 regulation in glomerular disease reveals a possible connection (A) . Renal cortical HPSE2 mRNA expression of HPSE1 KO mice treated with or without LPS for 2 days (B) . Renal cortical HPSE2 protein expression of HPSE1 KO mice treated with or without STZ for 16 weeks (C) . Renal cortical HPSE2 mRNA expression of type 2 diabetic mice treated with HPSE1 inhibitor SST0001 or left untreated (D) . Relative HPSE1 activity of untreated wild-type mice or HPSE2 KO mice (E) . Glomerular HS expression of untreated wild-type mice or HPSE2 KO mice. Data are expressed as mean ± SEM. n ≥ 3 * p < 0.05. HPSE2, heparanase-2; AU, arbitrary units; HPSE1, heparanase-1; KO, knock-out; STZ, streptozotocin.
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    Relation between <t>HPSE1</t> and HPSE2 regulation in glomerular disease reveals a possible connection (A) . Renal cortical HPSE2 mRNA expression of HPSE1 KO mice treated with or without LPS for 2 days (B) . Renal cortical HPSE2 protein expression of HPSE1 KO mice treated with or without STZ for 16 weeks (C) . Renal cortical HPSE2 mRNA expression of type 2 diabetic mice treated with HPSE1 inhibitor SST0001 or left untreated (D) . Relative HPSE1 activity of untreated wild-type mice or HPSE2 KO mice (E) . Glomerular HS expression of untreated wild-type mice or HPSE2 KO mice. Data are expressed as mean ± SEM. n ≥ 3 * p < 0.05. HPSE2, heparanase-2; AU, arbitrary units; HPSE1, heparanase-1; KO, knock-out; STZ, streptozotocin.
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    Image Search Results


    HPSE activity is dose-dependently inhibited by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide. Dose response inhibition of recombinant human HPSE with (A) unstimulated HS glx (B) . LPS HS glx , (C) . fucoidan and (D) . sulodexide. Data are expressed as mean ± SEM. Unstimulated HS glx , HS extracted from unstimulated endothelial glycocalyx; LPS HS glx , HS extracted from LPS stimulated endothelial glycocalyx; HPSE, heparanase-1.

    Journal: Frontiers in Molecular Biosciences

    Article Title: Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis

    doi: 10.3389/fmolb.2023.1223972

    Figure Lengend Snippet: HPSE activity is dose-dependently inhibited by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide. Dose response inhibition of recombinant human HPSE with (A) unstimulated HS glx (B) . LPS HS glx , (C) . fucoidan and (D) . sulodexide. Data are expressed as mean ± SEM. Unstimulated HS glx , HS extracted from unstimulated endothelial glycocalyx; LPS HS glx , HS extracted from LPS stimulated endothelial glycocalyx; HPSE, heparanase-1.

    Article Snippet: The inhibition of HPSE activity by unstimulated HS glx , LPS HS glx , fucoidan or sulodexide was determined by an in-house developed HPSE activity assay, which was validated by the use of recombinant active human HPSE (Cat#7570-GH-005, Bio-techne), and performed as described previously ( ).

    Techniques: Activity Assay, Inhibition, Recombinant

    Relation between HPSE1 and HPSE2 regulation in glomerular disease reveals a possible connection (A) . Renal cortical HPSE2 mRNA expression of HPSE1 KO mice treated with or without LPS for 2 days (B) . Renal cortical HPSE2 protein expression of HPSE1 KO mice treated with or without STZ for 16 weeks (C) . Renal cortical HPSE2 mRNA expression of type 2 diabetic mice treated with HPSE1 inhibitor SST0001 or left untreated (D) . Relative HPSE1 activity of untreated wild-type mice or HPSE2 KO mice (E) . Glomerular HS expression of untreated wild-type mice or HPSE2 KO mice. Data are expressed as mean ± SEM. n ≥ 3 * p < 0.05. HPSE2, heparanase-2; AU, arbitrary units; HPSE1, heparanase-1; KO, knock-out; STZ, streptozotocin.

    Journal: Frontiers in Pharmacology

    Article Title: Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

    doi: 10.3389/fphar.2023.1098184

    Figure Lengend Snippet: Relation between HPSE1 and HPSE2 regulation in glomerular disease reveals a possible connection (A) . Renal cortical HPSE2 mRNA expression of HPSE1 KO mice treated with or without LPS for 2 days (B) . Renal cortical HPSE2 protein expression of HPSE1 KO mice treated with or without STZ for 16 weeks (C) . Renal cortical HPSE2 mRNA expression of type 2 diabetic mice treated with HPSE1 inhibitor SST0001 or left untreated (D) . Relative HPSE1 activity of untreated wild-type mice or HPSE2 KO mice (E) . Glomerular HS expression of untreated wild-type mice or HPSE2 KO mice. Data are expressed as mean ± SEM. n ≥ 3 * p < 0.05. HPSE2, heparanase-2; AU, arbitrary units; HPSE1, heparanase-1; KO, knock-out; STZ, streptozotocin.

    Article Snippet: The inhibition of HPSE1 activity by HPSE2 protein and peptides was determined by the commercially available HPSE1 assay kit and an in-house developed HPSE1 activity assay, which was optimized by the use of recombinant active human HPSE1 (Bio-techne, Abingdon, United Kingdom, Cat#7570-GH-005).

    Techniques: Expressing, Activity Assay, Knock-Out

    Inhibition of HPSE1 activity is dose-dependently achieved by HPSE2 protein and HPSE2 peptides. Dose response inhibition of recombinant human HPSE1 with the full HPSE2 protein (A) and HPSE2 peptides (B,C) . HPSE2, heparanase-2; HPSE1, heparanase-1.

    Journal: Frontiers in Pharmacology

    Article Title: Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

    doi: 10.3389/fphar.2023.1098184

    Figure Lengend Snippet: Inhibition of HPSE1 activity is dose-dependently achieved by HPSE2 protein and HPSE2 peptides. Dose response inhibition of recombinant human HPSE1 with the full HPSE2 protein (A) and HPSE2 peptides (B,C) . HPSE2, heparanase-2; HPSE1, heparanase-1.

    Article Snippet: The inhibition of HPSE1 activity by HPSE2 protein and peptides was determined by the commercially available HPSE1 assay kit and an in-house developed HPSE1 activity assay, which was optimized by the use of recombinant active human HPSE1 (Bio-techne, Abingdon, United Kingdom, Cat#7570-GH-005).

    Techniques: Inhibition, Activity Assay, Recombinant

    HPSE2 protein and peptides treatment have beneficial effects in LPS-induced glomerulonephritis (A) . BUN, (B) . plasma creatinine, and (C) . Urinary albumin/creatinine ratio of mice injected with LPS (2 days) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix (D) . Cortical HPSE1, (E) . cortical TNF-α, (F) . cortical IL-6 mRNA expression of mice injected with LPS (2 days) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix of 381–410, 391–420, and 401–430. Data are expressed as mean ± SEM. n ≥ 4 * p < 0.05, ** p < 0.01, *** p < 0.001. HPSE2, heparanase-2; HPSE1, heparanase-1; Prt, His-mHPSE2 protein; pep, HPSE2 peptide mix of 381–410, 391–420, and 401–430; BUN, Blood urea nitrogen plasma level.

    Journal: Frontiers in Pharmacology

    Article Title: Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

    doi: 10.3389/fphar.2023.1098184

    Figure Lengend Snippet: HPSE2 protein and peptides treatment have beneficial effects in LPS-induced glomerulonephritis (A) . BUN, (B) . plasma creatinine, and (C) . Urinary albumin/creatinine ratio of mice injected with LPS (2 days) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix (D) . Cortical HPSE1, (E) . cortical TNF-α, (F) . cortical IL-6 mRNA expression of mice injected with LPS (2 days) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix of 381–410, 391–420, and 401–430. Data are expressed as mean ± SEM. n ≥ 4 * p < 0.05, ** p < 0.01, *** p < 0.001. HPSE2, heparanase-2; HPSE1, heparanase-1; Prt, His-mHPSE2 protein; pep, HPSE2 peptide mix of 381–410, 391–420, and 401–430; BUN, Blood urea nitrogen plasma level.

    Article Snippet: The inhibition of HPSE1 activity by HPSE2 protein and peptides was determined by the commercially available HPSE1 assay kit and an in-house developed HPSE1 activity assay, which was optimized by the use of recombinant active human HPSE1 (Bio-techne, Abingdon, United Kingdom, Cat#7570-GH-005).

    Techniques: Injection, Expressing

    HPSE2 protein and peptides treatment beneficially affect experimental STZ-induced diabetic nephropathy (A) . BUN, (B) . plasma creatinine, and (C) . Urinary albumin/creatinine ratio of mice injected with STZ (12 weeks) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix (D) . Cortical HPSE1, (E) . cortical TNF-α, (F) . cortical IL-6 mRNA expression of mice injected with STZ (12 weeks) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix. Data are expressed as mean ± SEM. n ≥ 5 * p < 0.05. HPSE2, heparanase-2; HPSE1, heparanase-1; Prt, His-mHPSE2 protein; pep, peptide mix; BUN, Blood urea nitrogen plasma level; STZ, streptozotocin.

    Journal: Frontiers in Pharmacology

    Article Title: Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

    doi: 10.3389/fphar.2023.1098184

    Figure Lengend Snippet: HPSE2 protein and peptides treatment beneficially affect experimental STZ-induced diabetic nephropathy (A) . BUN, (B) . plasma creatinine, and (C) . Urinary albumin/creatinine ratio of mice injected with STZ (12 weeks) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix (D) . Cortical HPSE1, (E) . cortical TNF-α, (F) . cortical IL-6 mRNA expression of mice injected with STZ (12 weeks) and treated with different concentrations of HPSE2 protein or HPSE2 peptide mix. Data are expressed as mean ± SEM. n ≥ 5 * p < 0.05. HPSE2, heparanase-2; HPSE1, heparanase-1; Prt, His-mHPSE2 protein; pep, peptide mix; BUN, Blood urea nitrogen plasma level; STZ, streptozotocin.

    Article Snippet: The inhibition of HPSE1 activity by HPSE2 protein and peptides was determined by the commercially available HPSE1 assay kit and an in-house developed HPSE1 activity assay, which was optimized by the use of recombinant active human HPSE1 (Bio-techne, Abingdon, United Kingdom, Cat#7570-GH-005).

    Techniques: Injection, Expressing